We're working with Sound with XNA this week. I introduced it yesterday and I'm going to demonstrate how to do it today.
The cool part is that we have all the tools you need for doing sound. Adobe SoundBooth, microphones, etc.
Looking forward to it. We'll be writing a "drum kit".
Here's a movie on using SoundBooth to make a decision. http://www.screencast.com/t/ZDFhNjJiNT